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Antifungals : From Genomics to Resistance and the Development of Novel Agents by Patrick Vandeputte (2015, Hardcover)

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Infections caused by pathogenic fungi are a significant global problem, a situation exacerbated by the limited availability of good antifungal options. Being eukaryotic organisms, these pathogens are phylogenetically much closer to the human host than bacterial pathogens. This sets serious limits to the range of exploitable fungal-specific drug targets. The advent of 'omics' and other high throughput technologies in recent years has revolutionized the field of antifungal research permitting researchers to quickly identify novel compounds and gain greater insights into drug resistance mechanisms. Researchers can analyze the whole organism's response to any particular condition or compound, thereby providing a deeper understanding of fungal biology and the host-fungus interaction. In this book, a panel of high-profile contributors provides an overview of current antifungal research. Chapters are written from a molecular and genomic perspective and contain speculative models upon which to base future research efforts. Topics include: the molecular mechanisms responsible for antifungal resistance to the classical molecules, azoles, polyenes, and echinocandins * fungal biofilms * fungal-specific biological pathways that constitute potential new targets * strategy to potentiate existing antifungal agents * impact of high throughput screenings of chemical compound collections * modulating the host response * antifungal vaccines * animals models. The book will be an essential reference for everyone with an interest in fungal pathogenesis. It is recommended for all biology and medical libraries. [Subject: Molecular Biology, Genomics, Life Science]

Product Identifiers

Publisher
Caister Academic Press
ISBN-10
1910190012
ISBN-13
9781910190012
eBay Product ID (ePID)
202471265

Product Key Features

Author
Patrick Vandeputte
Publication Name
Antifungals : from Genomics to Resistance and the Development of Novel Agents
Format
Hardcover
Language
English
Publication Year
2015
Type
Textbook
Number of Pages
344 Pages

Dimensions

Item Weight
38.1 Oz

Additional Product Features

Lc Classification Number
Rm410
Copyright Date
2015
Target Audience
Scholarly & Professional
Topic
Pathology, Pharmacology, Life Sciences / Mycology
Lccn
2015-304718
Dewey Decimal
616.9/69061
Dewey Edition
23
Illustrated
Yes
Genre
Science, Medical

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Antifungals : From Genomics to Resistance and the Development of Novel Agents by Patrick Vandeputte (2015, Hardcover)

About this product

Product Information

Product Identifiers

Product Key Features

Dimensions

Additional Product Features

Best Selling in Textbooks

Desk Reference to the Diagnostic Criteria from DSM-5-TR by American Psychiatric Association (2022, Trade Paperback)

PMBOK® Guide Ser.: Guide to the Project Management Body of Knowledge (PMBOK Guide) and the Standard for Project Management by Project Management Institute (2021, Trade Paperback)

Cognitive Behavior Therapy : Basics and Beyond by Judith S. Beck (2020, Hardcover)

NFPA 70® Handbook with Tabs : 2023 Edition by National Fire Protection Association (NFPA) (2022, Hardcover)

Self Heal by Design : The Role of Micro-organisms for Health by Barbara O'Neill (2018, Trade Paperback)

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Designing Data-Intensive Applications : The Big Ideas Behind Reliable, Scalable, and Maintainable Systems by Martin Kleppmann (2017, Trade Paperback)

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