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High Throughput Screening for Anticancer Drug Discovery by Avinash Kumar Seth, Ankur Javia and Sachin Chauhan (2012, Trade Paperback)

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Form screening of thiazole group of compounds against various tumor cell line like HL60 and MCF-7, from results of MTT and XTT assay, It was found out that thiazole derivative potentially inhibits the proliferation of MCF-7 cells (human breast cancer) but not others cells like HL60 (human leukemia) and VERO (African monkey's Kidney cell) presumably because of interaction of compounds with specific breast cancer cells. Initial screening was carried out by using MTT assay. Results obtained from MTT assay and XTT assay clearly indicates that out of 13 compounds only 6 compounds (2, 5, 8, 9, 10, and 13) show IC50 value below 100Î¼M and that was against only MCF-7 cell lines where as against HL60 cell line, compounds did not show any sign of cytotoxicity. IC50 value of cyclophosphamide was 16.72 Î¼M against MCF-7 cell line by MTT assay, which was higher than compound no. 5 (14.13 Î¼M) and 13 (11.10 Î¼M). Confirmatory screening was carried out by using XTT assay in which all six compounds ware found to be effective against MCF-7 cell line but with higher IC50 values compared to MTT assay.

Product Identifiers

Publisher
LAP Gmbh & Company KG
ISBN-10
3659162523
ISBN-13
9783659162527
eBay Product ID (ePID)
167839185

Product Key Features

Author
Ankur Javia, Avinash Kumar Seth, Sachin Chauhan
Publication Name
High Throughput Screening for Anticancer Drug Discovery
Format
Trade Paperback
Language
English
Publication Year
2012
Type
Textbook
Number of Pages
120 Pages

Dimensions

Item Length
9in
Item Height
0.3in
Item Width
6in
Item Weight
6.7 Oz

Additional Product Features

Topic
Pharmacology
Genre
Medical

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High Throughput Screening for Anticancer Drug Discovery by Avinash Kumar Seth, Ankur Javia and Sachin Chauhan (2012, Trade Paperback)

About this product

Product Information

Product Identifiers

Product Key Features

Dimensions

Additional Product Features

Best Selling in Textbooks

Diagnostic and Statistical Manual of Mental Disorders DSM-5-TR by American Psychiatric Association (2022, Trade Paperback)

Self Heal by Design : The Role of Micro-organisms for Health by Barbara O'Neill (2018, Trade Paperback)

Leadership : Theory and Practice by Peter G. Northouse (2021, Trade Paperback, Revised edition)

Research Design : Qualitative, Quantitative, and Mixed Methods Approaches by J. David Creswell and John W. Creswell (2022, Trade Paperback)

Designing Data-Intensive Applications : The Big Ideas Behind Reliable, Scalable, and Maintainable Systems by Martin Kleppmann (2017, Trade Paperback)

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Encyclopedia of Counseling : Master Review and Tutorial for the National Counselor Examination, State Counseling Exams, and the Counselor Preparation Comprehensive Examination by Howard Rosenthal (2017, Trade Paperback, Revised edition,New Edition)

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