Pheochromocytomas are rare but treacherous catecholamine-producing tumors, which if missed or not properly treated, will almost invariably prove fatal. Prompt diagnosis is, therefore, essential for effective treatment, usually by surgical resection. The manifestations are diverse and the tumor can mimic a variety of conditions, often resulting in either erroneous diagnoses or a delayed diagnosis.Reflecting the recent leaps in understanding this condition, Pheochromocytoma: Diagnosis, Localization, and Treatment provides a comprehensive update on the improvements in the diagnosis, localization, management and treatment of pheochromocytomas - providing you with the latest cutting edge science alongside best clinical practice. Written by the leading names in the field, the text details the significant developments in understanding the genetics and biology of the tumors, coupled with technological advances in the fields of analytical chemistry, genomics, molecular biology and nuclear medicine.
Product Identifiers
Publisher
Wiley & Sons, Incorporated, John
ISBN-10
1405149507
ISBN-13
9781405149501
eBay Product ID (ePID)
57282427
Product Key Features
Author
Graeme Eisenhofer, Karel Pacak, Jacques Lenders
Publication Name
Pheochromocytoma : Diagnosis, Localization, and Treatment
Format
Hardcover
Language
English
Publication Year
2007
Type
Textbook
Number of Pages
184 Pages
Dimensions
Item Length
9.9in
Item Height
0.6in
Item Width
7in
Item Weight
19.6 Oz
Additional Product Features
Lc Classification Number
Rc280.A3p33 2007
Reviews
"Important points are illustrated by tables [and] figures...that make the book easy to read. The information in this book is up to date and useful." Doody's Review Service
Table of Content
1 Introduction. 2 Historical comments. 3 Pathology. 4 Clinical presentation of pheochromocytoma . 4.1 Signs and Symptoms. 4.2 Differential Diagnosis. 4.3 Special Presentations. 4.3.1 Diagnosis of Pheochromocytoma in Patients with an Incidentally Discovered Adrenal Mass. 4.3.2 Pheochromocytoma as an Endocrine Emergency. 4.3.2.1 Hypertensive Crisis. 4.3.2.2 Hypotension and Shock. 4.3.2.3 Multisystem Failure. 4.3.2.4 Cardiac Emergencies. 4.3.2.5 Acute Peripheral Ischemia. 4.3.2.6 Pulmonary Emergencies. 4.3.2.7 Gastrointestinal Emergencies. 4.3.2.8 Nephrological Emergencies. 4.3.2.9 Neurological Emergencies. 4.3.3 Malignant Pheochromocytoma. 4.3.4 Pheochromocytoma in Children. 4.3.5 Pheochromocytoma in Pregnancy. 4.3.6 Pseudopheochromocytoma. 4.3.7 Factitious Pheochromocytoma. 5 Current trends in genetics of pheochromocytoma . 5.1 MEN Syndromes. 5.1.1 Diagnostic Approaches. 5.2 VHL Syndrome. 5.3 NF Type 1. 5.4 Succinate Dehydrogenase Gene Related Pheochromocytoma. 5.5 Genetic Problems in Sporadic and Other Pheochromocytomas. 6 Catecholamines and adrenergic receptors . 6.1 Synthesis and Sources of Catecholamines. 6.2 Synthesis of Catecholamines in Pheochromocytoma. 6.3 Storage and Release of Catecholamines by the Sympathoadrenal System. 6.4 Uptake and Metabolism of Catecholamines Produced by the Sympathoadrenal System. 6.5 Catecholamine Metabolism in Hepatomesenteric Organs. 6.6 Catecholamines Metabolism and Release by Pheochromocytoma. 6.7 Kinetics and Elimination of Catecholamines and Their Metabolites. 6.8 Pharmacology of Catecholamine Systems: Implications for Pheochromocytoma. 6.9 Physiology of Catecholamine Systems. 6.9.1 Adrenal Medullary Hormone System. 6.9.2 Peripheral Dopamine Systems. 6.10 Adrenergic Receptors and Their Functions. 6.11 Actions of the Catecholamines. 7 Current trends in biochemical diagnosis of pheochromocytoma . 7.1 Biochemical Tests of Catecholamine Excess. 7.2 Measurement Methods. 7.3 Reference Intervals. 7.4 Initial Biochemical Testing. 7.5 Follow-up Biochemical Testing. 7.6 Collection and Storage of Plasma and Urine Specimens. 7.7 Interferences from Diet and Drugs. 7.8 Pharmacologic Tests. 7.9 Additional Interpretative Considerations. 7.10 Summary. 8 Current trends in localization of pheochromocytoma . 8.1 Anatomical Imaging of Pheochromocytoma. 8.1.1 Computed Tomography. 8.1.2 Magnetic Resonance Imaging. 8.2 Functional Imaging of Pheochromocytoma. 8.2.1 MIBG Scintigraphy. 8.2.2 Positron Emission Tomography. 8.2.3 Somatostatin Receptor Scintigraphy (Octreoscan). 8.2.4 Current Imaging Algorithm. 9 Treatment of pheochromocytoma . 9.1 Medical Therapy and Preparation for Surgery. 9.2 Postoperative Management. 10 Future trends and perspectives. 10.1 Genomics in Pheochromocytoma Research. 10.2 Proteomics in Pheochromocytoma Research. 10.3 Future Therapeutic Modalities for Pheochromocytoma. References. Index