Playing the part of Major Dutch Schaefer you have been recruited by the CIA to go to Central America and help a squad of other recruits to free hostages who are being held by guerilla fighters. Once you arrive in Central America it becomes apparent that another force is at work, one that skins humans and takes their skulls.
Predator does not begin at the same point as the movie. When the game begins, your squad has already been eliminated by the Predator and it is now stalking you. There are a total of 30 screens to make your way through all while confronting the Predator, avoiding its sniper shots, and fending off guerilla fighters. Only one main weapon can be carried at a time; available weapons include rifles, machine guns, and flamethrowers.