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A Means to an End : The Biological Basis of Aging and Death by William R. Clark (1999, Hardcover)

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Why do we age? Is aging inevitable? Will advances in medical knowledge allow us to extend the human lifespan beyond its present limits? Because growing old has long been the one irreducible reality of human existence, these intriguing questions arise more often in the context of science fiction than science fact. But recent discoveries in the fields of cell biology and molecular genetics are seriously challenging the assumption that human lifespans are beyond our control.With such discoveries in mind, noted cell biologist William R. Clark clearly and skillfully describes how senescence begins at the level of individual cells and how cellular replication may be bound up with aging of the entire organism. He explores the evolutionary origin and function of aging, the cellular connections between aging and cancer, the parallels between cellular senescence and Alzheimer's disease, and the insights gained through studying human genetic disorders -- such as Werner's syndrome -- that mimic the symptoms of aging. Clark also explains how reduction in caloric intake may actually help increase lifespan, and how the destructive effects of oxidative elements in the body may be limited by the consumption of antioxidants found in fruits and vegetables. In a final chapter, Clark considers the social and economic aspects of living longer, the implications of gene therapy on senescence, and what we might learn about aging from experiments in cloning. This is a highly readable, provocative account of some of the most far-reaching and controversial questions we are likely to ask in the next century.

Product Identifiers

Publisher
Oxford University Press, Incorporated
ISBN-10
0195125932
ISBN-13
9780195125931
eBay Product ID (ePID)
1000257

Product Key Features

Author
William R. Clark
Publication Name
Means to an End : the Biological Basis of Aging and Death
Format
Hardcover
Language
English
Publication Year
1999
Type
Textbook
Number of Pages
256 Pages

Dimensions

Item Length
9.1in
Item Height
1.1in
Item Width
6.3in
Item Weight
19.8 Oz

Additional Product Features

Lc Classification Number
Qh608.C53 1999
Reviews
"Fascinating and informative.... One of the book's most engaging elementsis Clark's ability to show how scientists think about problems and approaches inthe field."--Booklist, "Clark effortlessly takes readers from the simple to the complex, from a discussion of single-celled organisms to human beings.... He also does a nice job of exploring the causes of Alzheimer's disease, various forms of cancer and an array of genetic disorders that afflict the young by makingthem age prematurely.... Neatly informative."--Publishers Weekly, "Why in spite of healthy, well-fed, well-watered lives do people age and die? The well-informed physician-researcher, William R. Clark, excitedly reveals new studies of progeric and normal mammals as he tracks teh inevitable corollary to human life: the inexorable rhythmic march to humandeath."--Lynn Margulis, Distinguished University Professor, Department of Geoscines, University of Massachusetts, Amherst and co-author of What is Life" and What is Sex", "Why in spite of healthy, well-fed, well-watered lives do people age anddie? The well-informed physician-researcher, William R. Clark, excitedlyreveals new studies of progeric and normal mammals as he tracks teh inevitablecorollary to human life: the inexorable rhythmic march to human death."--LynnMargulis, Distinguished University Professor, Department of Geoscines,University of Massachusetts, Amherst and co-author of What is Life" and What isSex", "Clark effortlessly takes readers from the simple to the complex, from adiscussion of single-celled organisms to human beings.... He also does a nicejob of exploring the causes of Alzheimer's disease, various forms of cancer andan array of genetic disorders that afflict the young by making them ageprematurely.... Neatly informative."--Publishers Weekly, "Fascinating and informative.... One of the book's most engaging elements is Clark's ability to show how scientists think about problems and approaches in the field."--Booklist
Table of Content
1. Aging, Senescence, and Lifespan2. The Nature of Cellular Senescence and Death3. The Evolution of Senescence and Death4. Of Embryos and Worms and Very Old Men: The Developmental Genetics of Senescence and Lifespan5. Human Genetic Diseases That Mimic the Aging Process6. Cycling to Senescence7. Replicative Immortality: Cancer and Aging8. Caloric Restriction and Maximum Lifespan9. With Every Breath We Take: Oxidative Stress and Cellular Senescence10. The Aging Brain11. A Conditional Benefit
Copyright Date
1999
Topic
Gerontology, Death & Dying, General, Life Sciences / Biology, Geriatrics
Lccn
98-018878
Dewey Decimal
612.6/7
Intended Audience
Trade
Dewey Edition
21
Illustrated
Yes
Genre
Science, Medical, Social Science

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A Means to an End : The Biological Basis of Aging and Death by William R. Clark (1999, Hardcover)

About this product

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All listings for this product

item 1 A Means to an End: The Biological Basis - hardcover, 0195125932, William R Clark

item 2 A Means to an End : The Biological Basis of Aging and Death Willi

item 3 A Means to an End: The Biological Basis of Aging and Death by Clark, William R.

item 4 Means to an End : The Biological Basis of Aging and Death William R. Clark

item 5 A Means to an End: The Biological Basis of Aging and Death by William R Clark

item 6 A Means to an End : The Biological Basis of Aging and Death by William R. Clark

item 7 A MEANS TO AN END: THE BIOLOGICAL BASIS OF AGING AND DEATH By William R. Clark

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PMBOK® Guide Ser.: Guide to the Project Management Body of Knowledge (PMBOK Guide) and the Standard for Project Management by Project Management Institute (2021, Trade Paperback)

Cognitive Behavior Therapy : Basics and Beyond by Judith S. Beck (2020, Hardcover)

Research Design : Qualitative, Quantitative, and Mixed Methods Approaches by J. David Creswell and John W. Creswell (2022, Trade Paperback)

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